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Clinical Studies in Enviromental Health—EPA

Study Results

Your participation makes a difference for the world.

Results of studies performed by the Human Studies Facility are published in prominent research and medical journals. They directly impact the creation of regulations responsible for protecting the health and environment of millions of Americans. For more information on health research, visit the EPA Health Research web site.

These are just some of the studies published by the EPA Human Studies Facility:

  • Pleil, J. and J. Sobus. Estimating lifetime risk from spot biomarker data and intra‚Äźclass correlation coefficients (ICC). Journal of Exposure Science and Environmental Epidemiology. Nature Publishing Group, 76(12):747-766, 2013.
  • Rotroff, D. M., D. J. Dix, K. A. Houck, T. B. Knudsen, M. T. Martin, K. M. McLaurin, D. M. Reif, K. M. Crofton, A. V. Singh, M. Xia, R. Huang, and R. S. Judson. Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals. Environmental Health Perspectives 2012. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, Open Access (Epub):1-39.
  • Gallagher, Jane, Edward Hudgens, Ann Williams, et. al. Mechanistic Indicators of Childhood Asthma (MICA) Study: piloting an integrative design for evaluating environmental health. BMC Public Health 2011, 11:344.
  • Breen, M., M. Breen, N. Terasaki, M. Yamazaki, and R. Conolly. Computational Model of Steroidogenesis in Human H295R Cells to Predict Biochemical Response to Endocrine Active Chemicals: Model Development for Metyrapone. Environmental Health Perspectives 2010. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 118(2):265-72.
  • Alexis, N.E., J. C. Lay, M. Hazucha, B. Harris, M.L. Hernandez, P.A. Bromberg, H. Kehrl, D. Diaz-Sanchez, C. Kim, R.B. Devlin, and D.B. Peden. Low-level ozone exposure induces airways inflammation and modifies cell surface phenotypes in healthy humans. Inhalation Toxicology 2010, 22:593-600.
  • Noah, T., K. Horvath, C. Robinette, and I. Jaspers. Effects of diesel exhaust on influenza-induced nasal inflammation. Presented at American Thoracic Society Annual Conference, San Diego, CA, May 15-20, 2009.
  • Tong, H., M. Gilmour, J. Samet, and R. Devlin. Ultrafine ambient particulate matter enhances cardiac ischemia and reperfusion injury. Presented at the American Thoracic Society Annual Meeting, San Diego, CA, May 15-20, 2009.
  • Sawyer, K., and M. Madden, Responses of human alveolar macrophages to diesel exhaust exposure: a lipidomics approach. Presented at Society of Toxicology Annual Meeting, Baltimore, MD, March 15-19, 2009.
  • Ghio, A, J. Soukup, and R. Sangani, Metals in air pollution particles decrease whole blood coagulation time. Presented at International Association for Breath Research. Cortmund, Germany, April 26-30, 2009.
  • Schneider, A., L. Neas, M. Herbst, R. Williams, M. Case, W. Cascio, A. Hinderliter, A. Peters, and R. Devlin. Endothelial dysfunction and inflammatory blood markers in association with exposure to central-site and personally measured fine particles in diabetic subjects. Presented at the Society for Environmental Epidemiology Annual Conference, Pasadena CA, October 12-16, 2008.
  • Schneider, A., L. Neas, M. Herbst, M. Case, R. Williams, W. Cascio, A. Hinderliter, et al. Endothelial dysfunction: associations with exposure to ambient fine particles in diabetic individuals. Environmental Health Perspectives 2008; 116(12):1666-1674.
  • Tong, H., M. Bassett, D. Graff, A. Hinderlither, M. Schmitt, R. Devlin, and J. Samet. Inhalation of diesel exhaust induces acute arterial vasoconstriction in healthy volunteers. Presented at American Thoracic Society Annual Meeting, San Diego, CA, May 15-20, 2008.